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Particular compounds existing in grapefruit are known to inhibit CYP450 3A4 and should increase the bioavailability of swallowed fentanyl (reportedly around 75% of a dose) and
PecFent is available in two different strengths: a 100 microgram for every spray bottle and also a four hundred microgram for every spray bottle. Make certain that you use the toughness that your health care provider has prescribed for you.
No, PecFent is specially created for breakthrough ache in cancer individuals who are currently on other opioid drugs.
Pill Administration: People should remove the tablet from the blister strip and straight away put the complete tablet inside the buccal cavity (over a rear molar, amongst the upper cheek and gum). Sufferers should not attempt to break up the pill. The pill really should not be chewed or swallowed, as this can result in reduced plasma concentrations than when taken as directed.
Typically Keep away from: Intake of grapefruit juice through cure with oral transmucosal formulations of fentanyl may perhaps bring about elevated plasma concentrations of fentanyl, which can be mostly metabolized by CYP450 3A4 isoenzyme inside the liver and intestine.
PecFent is often a ‘hybrid medication’. Because of this it is similar to ‘reference medicines’ made up of a similar Energetic substance, but given in another way.
You need to continue to keep PecFent in the child resistant storage container while you are not making use of it, even When you've got utilized all eight sprays. It is because PecFent may be life-threatening if taken by a toddler by chance.
Treatment method with PecFent must be began by and remain underneath the supervision of a physician who may have practical experience in controlling opioid therapy in most cancers sufferers. The physician should really Take into account the probable for PecFent for being abused.
PecFent is usually a medication used for the administration of click here breakthrough agony in Grownups with most cancers who will be presently obtaining opioid therapy.
If you pass up a dose, acquire it the moment you bear in mind. If It really is Nearly time to your following dose, skip the missed dose and continue together with your frequent plan.
Due to the fact PecFent is really a hybrid medication, the applicant presented knowledge on the reference medicines Together with results from its possess research.
Your physician will then help you obtain the appropriate dose to relieve your breakthrough pain. It is vital to adhere to your health care provider’s instructions.
Re-dosing individuals in just a one episode: Dosing may be repeated when through only one episode of breakthrough discomfort if ache is just not sufficiently relieved by just one PecFent dose. Re-dosing may perhaps occur 30 minutes right after the start of administration of PecFent and the exact same dosage energy need to be made use of.
weak spot, dizziness and reduced blood pressure level. Jointly these symptoms may be a signal of a perhaps everyday living-threatening condition identified as adrenal insufficiency, a condition by which the adrenal glands usually do not make plenty of hormones